The objective of this study was to analyze the association of bullying, eating disorders and drug use in adolescents from Chile and Spain. A secondary and high school sample of students (N= 960) from Chile (n= 666) and Spain (n= 294) participated in the study. Results indicate that students from both countries who act as bullies show a significant higher drug use than non-bullies. On the other hand, victims show a higher risk of eating disorders. Based on the effect size values, the strength of these associations are large and medium. On the contrary, to be a bully was not associated with eating disorders and to be a victim was not associated with drug consumption, except for tobacco use. On the other hand, while the prevalence of bullying is similar in both sub-samples, Spanish students show a higher use of substances and a higher risk of eating disorders. In conclusion, this study shows the connection between being a bully and drug use and between being a victim of bullying and eating disorders.