Personality and psychopathology differences were explored among a clinical sample of 52 patients with Panic Disorder (PD), with Agoraphobia (PDA) or without Agoraphobia, and two nonclinical samples, one with 45 participants with high anxiety sensitivity (AS) scores, and 55 with low AS scores. The clinical sample was evaluated according to DSM-IV-TR (APA, 2000) criteria. The participants in nonclinical samples were assigned depending on the “Anxiety sensitivity index” (ASI; Reiss, Peterson, Gursky, & McNally, 1986) scores. The “Brief symptom inventory” (BSI; Derogatis & Melisaratos, 1983) was used to assess general psychopathology and the “NEO personality inventory- revised” (NEO-PI-R; Costa & McCrae, 1992) was used to measure personality, both in the three samples. The results show that the only statistically significant differences between the participants with high AS scores and PD/PDA patients were in the psychopathological scales, phobic anxiety and paranoid ideation, and in the personality facet, social anxiety.