The aim of this work was to obtain the best cut-off point for the International Personality Disorder Examination Questionnaire (IPDEQ), DSM-IV Module. The sample involved 50 smokers who required treatment to stop smoking and whose screening was positive for at least one personality disorder (PD). They were subsequently evaluated by means of the full IPDE interview. The most appropriate cut-off points for antisocial and paranoid PD in these individuals were three and four positive criteria, respectively, whereas no conclusive results were forthcoming for all the other PDs. The kappa coefficient also shows good inter-evaluator reliability. The cut-off for three or more items is inadequate, as it significantly overestimates the presence of a PD. We conclude that the IPDEQ is useful for quickly determining the possible presence or absence of a PD, provided the cut-off point is raised until it is consistent with the diagnostic criteria proposed by the DSM-IV for each PD.