The aim of the study was to assess and compare the presence of personality disorders in a sample of 202 smokers who underwent psychological treatment to stop smoking and a sample of 211 nonsmokers from the general population. For the evaluation of the personality disorders we used the Spanish version of the Millon Clinical Multiaxial Inventory-II (MCMI-II; Millon, 1997). The results show that smokers obtain higher scores than nonsmokers in the phobic scale, the histrionic scale and the passive – aggressive scale. On the other hand, nonsmokers score higher in the compulsive scale. We found that smokers score higher than nonsmokers in anxiety scale, in somatoform scale and in dysthymic disorder, as well as in sincerity and in alteration scales. This relationship was kept after controlling the effect of the gender and age of the subjects. We concluded that some personality disorders, in particular, the histrionic, the avoidant, and the passive-aggressive, are more frequent in smokers. Future research is needed for the other subtypes