There is a feminization of migration subjected to high levels of stress in Spain. The purpose of this article is to study the relationship between migration on stress and psychopathology, and their impact on quality of life. The sample consists of immigrant and non-immigrant women subjected to high levels of overall stress. There were statistically significant in intensity of stress, stress-related finance and depression, with higher levels of impairment on immigrant women. In relation to quality of life, the intensity of stress predicted the degree of interference on physical health and bodily pain in daily activities. The stress associated with finances was a predictor of mental health. These data can be explained by the migration fact, due to economic, social and adaptive adversity, as well as the triple discrimination suffered by immigrant women.