The goal of the present study was to analyze the ways in which job-role quality and anger have direct or indirect influence on the reported presence of desease symptoms, risk habits of health and cholesterol (HDL/LDL), in a sample of 402 working women between 27 and 71 years of age. A set of scales were applied in order to measure: symptoms report, health risk habits, anger-in, anger-out and job-role quality. A blood sample was taken to evaluate the lipid profile. Using a Path analysis it was found that, health risk habits were associated with more symptoms reported. Direct relationship between job rewards and cholesterol levels were observed as well as between anger-in and LDL cholesterol. Job-role concerns have an effect on the LDL cholesterol mediated by anger-in. The findings allowed verifying relations in the health area, emotions and role quality in working women. These findings can be very useful for intervention programs in organizational settings