Throughout the world, major depression (MDD) is a prevalent and serious health problem. Relapse/recurrence of MDD occurs in well over 50% of those individuals who suffer from the disorder, so it is a chronic health problem. We reviewed and summarized the research findings for demographic, clinical, and other pathological conditions associated with relapse/recurrence of MDD. We concluded by offering some suggestions of how these variables interact to increase the risk of relapse/recurrence of the disorder.